The guide discusses the differences between bridged USDC and native USDC, focusing on the Sei Mainnet and providing best practices for migrating from bridged USDC, which is created through third-party applications like Noble, to native USDC, issued by Circle. Native USDC, fully backed by liquid cash and redeemable 1:1 for US dollars, is highlighted as the preferred choice due to its stability and compatibility with Circle's Cross-Chain Transfer Protocol (CCTP). To facilitate this migration, developers are encouraged to implement swapping mechanisms or liquidity pools within their applications on Sei Mainnet, or utilize decentralized exchanges for users to transition from USDC.n to native USDC. The document also underscores the importance of clearly distinguishing between the two forms of USDC by using correct token symbols and contract addresses, and suggests updating user interfaces to make native USDC the default option for financial transactions. Furthermore, it provides methods for accessing native USDC on Sei Mainnet, including using DeFi protocols, applying for a Circle Mint account, or employing CCTP-enabled bridge apps.