Amr Awadallah, founder and CEO of Vectara, emphasizes that technology is worthless without a problem to solve. Great tech should solve a common problem that impacts many people. Amr's guiding principle is whether there is a problem in the first place, and he advises tech founders to ask themselves this question before starting a company. He also highlights the importance of product market fit and culture in building a successful startup. Additionally, Amr stresses the need for growth through specializing in learning, encouraging people to never be shy about learning new things and embracing challenges to find what excites them within available tools and ideas.