ApeWorX, or "Ape," is a Python-based smart contract development framework that offers a customizable and safe environment for private key management, emerging as a potential successor to the Brownie framework. The Ethereum Python community, known for its collaboration, includes contributors from frameworks like Vyper and Brownie, who are now participating in Ape's development. Ape provides a flexible plugin system for integrating different programming languages and networks, distinguishing itself from other frameworks by separating networks into ecosystems and chains. It enhances security by encrypting and storing private keys locally, requiring a password for access, thus minimizing the risk of accidental exposure. Ape supports writing tests using pytest, and its interactive console allows developers to work within their chosen network environment. It is gaining traction among Python enthusiasts and DeFi protocols like Curve, and invites contributions from those looking to improve the framework further.