When managing Kubernetes workloads, pod disruption budgets (PDBs) are crucial for ensuring high availability during voluntary and involuntary disruptions. By setting the minimum number of pods an application needs to function smoothly during disruptions, PDBs provide a safety net, minimizing downtime and ensuring continuity of services. To create a PDB, one must carefully consider the application's availability needs, define appropriate selectors, and apply the YAML file using kubectl commands. Effective use of PDBs involves checking its status, simulating disruptions, and making necessary updates or deletions. Best practices include understanding applications, using selectors wisely, opting for percentage-based disruption budgets, combining with higher-level concepts, accounting for involuntary disruptions, monitoring PDBs regularly, and reviewing and revising them periodically. Real-world examples of PDBs in action include e-commerce platforms, financial services, telecommunications industry, SaaS platforms, and healthcare industry, where they help balance system maintenance with user experience and ensure constant availability. By using pod disruption budgets, developers can optimize Kubernetes resource limits and boost their cluster's performance and cost-efficiency.