MLflow has become a leading platform for tracking ML projects throughout their lifecycle, but building and running AI models in the cloud can be costly. To reduce costs, teams can choose the right infrastructure, pick machines from specific instance families that are optimized for GPU-dense applications, analyze workload requirements, use spot instances for non-critical tasks, and automate instance provisioning. Additionally, optimizing resource utilization by using containerization and orchestration tools, monitoring resource consumption, implementing resource pooling and sharing, compressing data, caching intermediate results, implementing data lifecycle policies, and monitoring and optimizing costs for AI model deployments can also help reduce cloud bills. Furthermore, investing in training and skill development to stay updated on the latest cost-saving techniques is crucial. By following these best practices, teams can run MLflow cost-effectively, especially when it comes to cloud-based AI models.