The COVID-19 pandemic has led to a sharp increase in online grocery shopping, with over 40% of UK adults buying more items online than usual. To cope with this surge, retailers are implementing various systems and policies, including virtual queueing, restricted usage for healthcare workers and vulnerable customers, and limiting new customer signups. However, the biggest constraint is not the number of vans or drivers, but rather the capacity in customer fulfillment centers. Spatial optimization can help by decreasing the number of routes and increasing deliveries, allowing retailers to better manage their supply chain networks. This can be achieved through various techniques, such as on-demand last-mile delivery, territory definition, and supply chain network design, which can help retailers adapt to changing consumer behavior and prepare for the post-COVID-19 era.