Anthropic and the US Department of Energy (DOE) have formed a multi-year partnership under the Genesis Mission, an initiative aimed at using AI to enhance America's scientific leadership. This collaboration focuses on energy dominance, biological and life sciences, and scientific productivity, affecting all 17 national laboratories in the US. Anthropic will provide DOE researchers access to its AI model, Claude, and a team of engineers to develop tools like AI agents and Model Context Protocol servers. The partnership aims to speed up energy permitting processes, advance nuclear technology, support drug discovery, and improve scientific productivity by leveraging decades of DOE research data. This initiative marks a significant step in integrating AI with America's scientific research infrastructure, building on past collaborations such as the development of a nuclear risk classifier and implementing AI tools at national laboratories. Anthropic's involvement seeks to shape how AI and human researchers collaborate, promoting scientific advancements that benefit society.