The talk discusses the importance of securing cloud native communication from end user to service, particularly in hybrid and multi-cloud environments. The speakers highlight the need for defense-in-depth security measures, including identity verification, access control lists, and mutual TLS (mTLS) authentication. They also discuss the challenges of network heterogeneity and the importance of observability, reliability, and security in service meshes. The presentation showcases a demo using Console Connect and Ambassador API Gateway to secure end-to-end communication between services, demonstrating how to mitigate man-in-the-middle attacks and ensure secure data transmission. The speakers emphasize the need for incremental and continuous security measures, including scanning dependencies, container security, and network security, to prevent gaps in the security posture.