This week's contest is focused on building a Twilio-powered voice application for non-profits, with the goal of helping organizations implement a voice solution and winning a $500 prize in Twilio credits. Non-profits can explore various ways to utilize voice technology, such as creating an education platform like Donors Choose, facilitating community exchange through The Freecycle Network, or supporting animal welfare initiatives like the ASPCA. To get started, non-profits can leverage resources like Google Checkout and NTEN, a membership organization for nonprofit professionals who use technology to drive their causes. If you're a non-profit in need of a voice application, you can reach out to Twilio's support team for guidance and collaboration opportunities.