The Twilio Developer Contest is now open, where developers can submit their best Twilio-powered business for a chance to win prizes including an Amazon Kindle 3G and $100 in Twilio credit. The contest aims to encourage developers to try Twilio for different use cases and industries, with categories announced weekly to inspire creativity. To get involved, submissions can be made through the official website, and resources such as documentation, ebooks, and webinars are available to help developers succeed with Twilio.