To initiate a call using ColdFusion and the Twilio Voice API, replace placeholders with your actual account information, caller ID, target phone number, and URL to execute. The CFHTTP tag is used to send a POST request to the Twilio API with parameters such as Caller, Called, and URL. Upon successful execution, the response from Twilio can be displayed in a textarea, showing the HTTP status code and the raw response content. This example provides a starting point for integrating Twilio's call-making functionality into ColdFusion applications.