NODES 2021 is a live, fully immersive experience that will be different from traditional virtual conferences. The event aims to combat "zoom fatigue" and provide an engaging, interactive experience for attendees. Over 50 talks across five tracks will be delivered live, with scheduled breaks and an interactive Q&A panel. Pre-NODES will also take place before the main event, allowing people to join in remotely. Attendees are encouraged to register early, plan their day, join the Discord server, and prepare their environment for a comfortable viewing experience. The event is expected to be unique and enjoyable, with something special planned for the main break.