Building a multi-region or multi-cloud environment for applications involves complex challenges, particularly in networking, security, and operations, to ensure efficient and secure connectivity across different cloud platforms and on-premise environments. Essential strategies include employing a scalable hub-and-spoke transit architecture, supporting diverse communication requirements, and integrating network services like firewalls without re-architecting the system. Aviatrix and Kong offer solutions to streamline these processes; Aviatrix focuses on simplifying networking connectivity, while Kong provides technologies like its API gateway and Kuma service mesh to facilitate microservice-based distributed architecture. Together, these tools help architects design and control multi-cloud application platforms by supporting diverse topologies and meeting technical and business needs without necessitating deep cloud expertise.