Migrating a Grafana configuration database from PostgreSQL to MySQL/MariaDB can be streamlined by following a series of steps, starting with creating an empty MySQL database and adjusting the Grafana configuration to connect to it. The process involves exporting tables from the PostgreSQL database and using a series of SED commands to ensure compatibility with MySQL, such as removing PostgreSQL-specific statements and adjusting schema notations. After exporting the data to a file, it can be imported into MySQL, allowing Grafana to use the new database setup upon restarting. This approach requires certain assumptions for simplicity, such as both databases running on the same server without security constraints, but adjustments may be necessary in production environments.