The process of collecting Prometheus metrics using the OpenTelemetry Collector and Grafana involves configuring the OpenTelemetry Collector to act as a proxy that receives, processes, and exports telemetry data in various formats, including Prometheus. The setup involves installing Node Exporter on a server to expose metrics, creating a Grafana Cloud account to store and visualize these metrics, and configuring both the OpenTelemetry Collector and Prometheus to scrape and send data to Grafana Cloud. The OpenTelemetry Collector's pipeline consists of receivers, processors, and exporters, which collect telemetry data, process it, and send it to designated outputs. Once configured, the metrics can be visualized in Grafana using pre-built dashboards, providing insights into server performance. Future discussions will explore deploying the collector in Kubernetes and using Prometheus components more efficiently.