GitHub's infrastructure team successfully executed a major MySQL database migration to a new datacenter, enhancing the performance and speed of GitHub.com. This complex transition involved meticulous planning, testing, and configuration adjustments, such as tuning MySQL settings and partitioning large tables to optimize resources. The team employed tcpdump for realistic workload testing and ensured a seamless switchover by following a comprehensive checklist, announcing a maintenance window, and coordinating globally through pull requests. Post-migration, the average page load time was halved, demonstrating the effectiveness of their approach. The project highlighted the importance of extensive testing, collaboration, and strategic resource management, leading to improved performance and reliability, with plans for further enhancements underway.