Puppeteer and Selenium are both open-source libraries used for automating browser interactions, but they differ in their approaches and use cases. Puppeteer is a Node.js library optimized for Chrome or Chromium browsers and offers high-level API control via the DevTools Protocol, making it suitable for JavaScript-centric environments and tasks like automated testing, page rendering, and web scraping. Selenium, on the other hand, is a more mature framework supporting multiple browsers such as Chrome, Firefox, Safari, and Edge, and various programming languages, making it ideal for cross-browser testing and complex scenarios. While Puppeteer is faster and more efficient in headless mode, Selenium provides broader compatibility and a larger ecosystem with extensive documentation and community support. Both tools can be integrated with the Bright Data Scraping Browser to enhance their web scraping capabilities by overcoming website access restrictions.