A region failure occurs when a cloud provider's data center or availability zone (AZ) becomes inaccessible due to physical damage, natural disasters, or other catastrophic events. This can lead to high availability and disaster recovery issues, as synchronous replication within the same region may not be sufficient to ensure continuity. In contrast, asynchronous replication across regions increases latency but provides more protection against larger natural catastrophes. A multi-cloud provider configuration is ideal for ensuring high availability over cloud region failures, as it allows at least one of the providers to remain operational even if another fails. YugabyteDB, a distributed SQL database, can help mitigate this risk by providing bi-directional replication across multiple regions and AZs, ensuring fast read and write operations while minimizing data loss in case of failover.