Video conferencing is increasingly essential yet complex for developers to implement, often requiring frameworks like React Native and WebRTC to create applications for real-time communication. React Native facilitates the development of native mobile applications for both iOS and Android using JavaScript, allowing code sharing across platforms. WebRTC, an open-source protocol, enables peer-to-peer communication through voice, text, and video, utilizing technologies like SDP, ICE, and RTP, along with a signaling server for connection establishment. A step-by-step guide is provided for building a video call application using Node.js with SocketIO as the signaling channel and React Native for the client-side app, including setting up permissions and configurations for Android and iOS. The guide also covers creating the user interface, establishing WebRTC calls, managing local and remote media streams, and handling audio routing using third-party libraries. For simpler integration, Video SDK is recommended as it offers a more developer-friendly approach to incorporating live video and audio into React Native projects with enhanced customization and data access capabilities.