You can integrate Claude, Anthropic's AI assistant with Twilio Voice using ConversationRelay. Twilio's ConversationRelay allows you to build real-time voice applications with AI Large Language Models (LLMs) that you can call using Twilio Voice. This tutorial demonstrates a basic integration of Claude with Twilio Voice using ConversationRelay. To deploy this tutorial, you need Node.js 23+, a Twilio account and phone number, an Anthropic account and API Key, Ngrok or another tunneling solution, and your code editor or IDE of choice. You create a project directory, initialize a new Node.js project, install the necessary packages, configure environment variables, write the server code, start ngrok and the server, configure Twilio, and test your integration. The code integrates Claude with Twilio Voice using ConversationRelay in under 100 lines of code, allowing you to build real-time voice applications with AI LLMs that can engage in conversation with an Anthropic model.