Boosting Postgres performance is achieved by adopting prepared statements in applications, which skips query parsing and analyzing, reducing overhead. Pairing with a connection pooler and transaction mode can dramatically improve database performance. Prepared statements are queries that accept parameters, pre-compiling the query on the server side, allowing for improved execution time. To use them effectively, developers should ensure their application uses the libpq version of creating prepared statements through the Object-Relational Mapping (ORM) implementation. The recommended configuration for Timescale allows 100 prepared statements to maximize efficiency in PgBouncer's cache. By adopting this approach, applications can achieve a performance win while boosting Postgres database performance.