XSS attacks are a type of vulnerability that can compromise user browser environments, and Django offers built-in protections against them, but it's essential to follow best practices such as quoting dynamic data, avoiding template literals, validating attribute URLs, escaping JavaScript and CSS data, and limiting the use of certain filters. Using dedicated security tools like Snyk can help detect and fix XSS vulnerabilities early in development, reducing the risk of these attacks occurring in Django applications.