To prevent open redirect vulnerabilities in Laravel, it is essential to implement fixed redirects that confine redirections to specific, trusted routes within the application, define a list of trusted destinations, and disallow redirections to external domains. Additionally, using Snyk IDE extensions can detect open redirect vulnerabilities and provide actionable insights to fortify the security posture of Laravel applications. By following these strategies, developers can significantly enhance the security of their applications and ensure users are only redirected to trusted and predefined locations.