Django, a widely-used Python web framework, simplifies web development by providing a robust permissions system integral for securing applications. Permissions in Django are foundational to role-based access control, allowing developers to manage user access at the object level via models, which automatically generate default CRUD permissions. Developers can also create custom permissions, such as for publishing or featuring posts in a blog app, which are best defined before initial migrations to ensure proper database setup. Django's tools for managing permissions include programmatic methods, the built-in Django admin GUI, and custom solutions like Retool for more complex workflows. While Django admin offers basic permission management, it may become inefficient for larger applications, prompting developers to consider custom tools, which can cater to advanced scenarios and provide more scalable solutions.