React Native and Expo CLI offer distinct advantages for mobile app development, with Expo increasingly favored due to its streamlined processes and support from the React Native core team. Originally, Expo had limitations, particularly with native libraries and in-app purchases, but recent updates, including EAS Build and Expo Dev Clients, have addressed many of these concerns, enhancing compatibility with native features and expanding development capabilities. Expo Go, a key component, allows for easy testing via QR code but initially lacked support for native libraries; however, Expo SDK libraries and the ability to create custom Dev Clients have mitigated this issue. The Expo Application Service (EAS) further facilitates app development and submission processes, although it requires a paid subscription for full features. Despite some historical objections, Expo's advancements have largely dispelled concerns about app size, build resources, and support for features like WebRTC, making it a preferred choice for developers who value ease of use and efficiency.