Choosing the right Node.js framework for your project involves weighing various factors such as performance, community support, ease of use, and the specific needs of your application. Express is a popular, fast, and minimalist framework with a large community, suitable for both small and large projects, while Sails offers more built-in features and is ideal for medium-sized projects that require quick setup. Meteor is well-suited for rapid prototyping and small projects, providing extensive documentation and easy integration with front-end technologies. Loopback, developed by IBM, is focused on creating APIs and microservices with minimal coding and is best for enterprise-scale projects. The decision ultimately depends on whether you prioritize flexibility and customization or prefer built-in tools for rapid development, and it is recommended to explore documentation and experiment with different frameworks to find the best fit for your app or team.