Creating a weather website involves several key steps, starting with obtaining an API key from RapidAPI to access weather data from OpenWeatherMap, which provides real-time and forecast information from over 40,000 weather stations. The project setup requires Node.js for server-side applications and Express.js as the web framework, with the creation of directories and files such as app.js and index.html to house the main code and HTML templates. AJAX is utilized to handle form submissions and dynamically display weather data based on user input. The guide emphasizes the importance of understanding and effectively using JSON data from API responses to build a functional site capable of responding to real-time client queries. Following these steps allows one to create a weather website from scratch, equipped to make API calls and present weather updates efficiently.