Python's *args and **kwargs provide a dynamic means of handling arbitrary numbers of positional and keyword arguments in function definitions, offering significant flexibility in coding. While widely used in frameworks like Django, where they allow for versatile function calls, their use comes with certain drawbacks. These include reduced code readability, lack of type checking, and potential maintenance challenges, as changes to argument order or function signatures may lead to unintended behavior. The balance between flexibility and explicitness is crucial, as emphasized by the Zen of Python's principle "explicit is better than implicit." Developers are encouraged to use these tools judiciously, enhancing code clarity with descriptive argument names and type annotations, thereby reducing the risk of subtle bugs and ensuring robust, maintainable code.