Separating configuration from code is essential to maintainability and security, and the article discusses three Python libraries that facilitate this process: python-dotenv, python-decouple, and dj-database-url. Python-dotenv allows developers to store environment variables in a .env file and access them using simple code without altering the environment, thereby preventing sensitive information from being committed to version control systems like Git. Python-decouple offers similar functionality but with the added convenience of casting and default values, especially useful in Django applications for managing configuration variables. Lastly, dj-database-url helps manage database connection settings by parsing a database URL into a Django-compatible configuration dictionary, simplifying the process of setting up database connections in web applications. The article underscores the importance of adhering to The Twelve-Factor App principle of separating config from code and provides practical code snippets and tips to aid developers in implementing these practices effectively.