Running multiple Flask applications simultaneously on different ports is straightforward by specifying a different port number in the `app.run()` function, which prevents port conflicts and allows each app to be accessed independently. By default, Flask runs on port 5000, which can cause issues if two apps are launched simultaneously, as the first app takes precedence and all requests are routed to it, resulting in errors for pages unique to the second app. While using Flask's built-in development server is sufficient for testing or home network setups, it is recommended to use a production-ready server like nginx for a more reliable environment. The text raises questions about whether Flask is suitable for production-level applications or if one should transition to Django for larger projects, inviting discussion on best practices for deploying Flask apps in different contexts.