Proper error handling in Python can enhance code simplicity, readability, and adherence to idiomatic practices. Key approaches include using explicit rather than implicit exceptions and ordering specific exceptions before general ones to avoid catch-all scenarios. Raising exceptions can help prevent unnecessary code indentation, and creating custom exceptions provides clearer communication with function callers. Narrow try/except blocks are recommended to reduce the temptation of handling too many exceptions, and the "easier to ask for forgiveness than permission" (EAFP) principle is preferred over excessive condition checking. Verbose logging, particularly using logger.exception, aids in capturing stack traces, and tools like Sentry can alert developers to unexpected errors, providing full stack traces for efficient debugging.