The guide explores best practices for building efficient serving infrastructure for open-source large language models (LLMs), focusing on GPU autoscaling, inference throughput enhancements, and cost-effective deployment strategies. It highlights the importance of delivering fast and scalable AI solutions, not just high-quality models, and addresses key challenges in provisioning GPUs in dynamic environments. Predibase's intelligent serving infrastructure is showcased, featuring innovations like Turbo LoRA for improved throughput without sacrificing quality, and LoRA Exchange for running multiple model variants on a single GPU. These approaches allow for significant cost savings and enhanced performance by optimizing resource allocation and reducing latency, particularly with smart autoscaling and cold start time reduction. The guide underscores the value of open-source models for flexible deployment and cost efficiency, presenting detailed insights into optimizing AI inference infrastructure for enterprise applications.