Creating an empty database on PlanetScale allows for easy population with data from a script file, streamlining the process of managing large numbers of commands. To achieve this, users need to have a PlanetScale account and the CLI installed, as well as a script containing SQL commands. By utilizing the `pscale shell` command with the `<` operator, users can pipe in commands from their script file, creating a new database with a populated schema in a single step. Once created, users can interactively run queries on the database using the PlanetScale CLI.