MySQL replication is a crucial step in providing high availability for MySQL databases. To ensure data is always available, proper configuration of replication is necessary. The best practice is to use an active/passive configuration, where one server acts as the source and all other servers are read-only replicas from that source. Using Global Transaction Identifiers (GTIDs) can help reduce the risk of data getting out of sync based on transactions not being processed or being processed more than they should. The correct replication mode, such as semi-synchronous replication, is also essential to ensure data consistency and minimize latency. Additionally, monitoring replication, creating a failover strategy, and considering replication across different regions are crucial considerations when configuring MySQL replication. By understanding these best practices and configurations, businesses can improve the reliability and performance of their MySQL databases.