Connecting Docker Hub to Octopus Deploy can be straightforward, but for those opting out of using a public Docker registry, alternatives like JFrog Artifactory or Sonatype Nexus are viable options. While the open-source version of Nexus includes comprehensive operational features, the paid version offers additional benefits like High Availability and advanced authentication. To create a Docker registry in Nexus, users need to navigate through the Server Administration tab to set up a docker (hosted) repository, noting that a specific port assignment, such as 8443, is necessary for tagging images. Once the registry is set up, connecting it to Octopus Deploy involves creating an external feed in the Octopus Deploy library, specifying the feed type, name, and URL while leaving the registry path blank and entering credentials if required. This process, although unique in its handling of Docker registries compared to other repository types, allows for successful integration and deployment.