At Nylas, diagnosing memory leaks in Go services involves utilizing tools like pprof and minikube to identify the root causes of memory issues in microservices built with Golang and deployed on Kubernetes. Despite Golang's efficient garbage collection, memory leaks can occur, leading to pod restarts when memory limits are exceeded, potentially affecting service availability. Profiling tools such as pprof help visualize memory allocation, pinpointing functions responsible for leaks, such as those involving unbounded global variables, hanging go routines, or unclosed file streams. Developers are advised to audit code for such patterns and reproduce leaks locally using Minikube, as production environments can complicate analysis. The guide emphasizes the importance of careful resource management and offers a repository for experimenting with memory leaks, ensuring developers can effectively troubleshoot and optimize their Go applications.