Building a Django application with Neon's serverless Postgres allows for quick and efficient setup of development environments that incur compute fees only when active, suitable for both serverless and long-lived applications. The process involves creating a Django project, configuring it to connect to Neon's Postgres database, and using Python tools like pyenv and venv to manage environments. Essential steps include setting up a virtual environment, installing Django, and configuring the database connection using environment variables. The application development process includes creating data models, defining views, and rendering data as web pages, followed by deploying the application with Gunicorn for production scalability. Performance optimizations, such as enabling persistent database connections, can significantly enhance application throughput. Neon's compatibility with Django and its autoscaling capabilities make it a practical choice for developers seeking a flexible and efficient database solution, with the added support of community resources for collaborative problem-solving.