Cloudflare's Hyperdrive is a globally distributed connection pooler and caching service designed to optimize database performance for serverless environments like Neon on Cloudflare Workers. It addresses the challenges of maintaining persistent database connections across requests by pooling connections to minimize overhead, caching read queries at the edge to reduce redundant database calls, and optimizing routing for write queries through Cloudflare's network. This reduces latency by allowing Cloudflare Workers to connect to the nearest Hyperdrive node rather than the database directly, thereby minimizing network round-trips. While Hyperdrive and Neon's connection pooler both manage database connections, Hyperdrive's global pool distribution makes Neon's pooling unnecessary, and it is recommended to use Hyperdrive directly with standard Postgres drivers instead of Neon's serverless driver. Users are encouraged to integrate Hyperdrive with Neon for building serverless applications to enhance performance, particularly in reducing connection overhead and optimizing globally distributed read and write queries.