AI-native companies are redefining their operational models by integrating artificial intelligence into the core of their processes, distinguishing themselves from traditional organizations that merely use AI as a tool for specific tasks. In the "Agents of Data" podcast, Matillion's Julian Wiffen and Sam Perrin discuss this transformative shift, emphasizing the role of Chief Data Officers (CDOs) in leading the transition to AI-native operations. Unlike traditional firms that deploy isolated AI pilots, AI-native companies leverage agent-driven workflows to enhance human capabilities across all functions. The conversation highlights the critical importance of knowledge curation, as AI agents need context to function effectively, which elevates the role of "knowledge curators" who maintain essential business logic and data standards. Additionally, the need for an "Evaluation Gym" is discussed, a testing environment to rigorously evaluate AI performance and ensure reliability. This shift requires strategic leadership and a focus on high-value use cases to maximize productivity gains, urging organizations to embrace continuous reinvention to remain competitive.