React, a popular JavaScript library created by Facebook, is renowned for building dynamic web UIs, and its ecosystem has expanded to include React Native for cross-platform mobile apps and react-native-windows for native Windows and macOS applications. React Native allows developers to use a single codebase to create applications for iOS, Android, and now Windows, thanks to Microsoft's extension, react-native-windows, which supports native platform-specific UI rendering. This guide provides detailed instructions on setting up a development environment for building Windows desktop applications with react-native-windows, including necessary system requirements and step-by-step commands to initialize and run a React Native project as a Windows app. It highlights the development process, including potential errors during the build and solutions, and demonstrates creating a simple Universal Windows Platform (UWP) app using React Native components and APIs. The react-native-windows project, which can render UWP UI elements from a JavaScript codebase, supports complex layouts and integrates with various React Native libraries, making it a versatile tool for developers aiming to build high-quality Windows desktop applications.