The debate between using CSS Grid and CSS frameworks such as Bootstrap hinges on several factors, including ease of use, browser support, performance, and responsiveness. CSS frameworks are advantageous for developers who prefer using predefined components and classes, offering better support for legacy browsers, and handling responsiveness with helper classes. However, they may incur performance issues due to larger asset sizes and render-blocking CSS. In contrast, CSS Grid offers a more flexible, native solution for defining layouts and responsiveness directly in CSS, with growing browser support and better performance outcomes. The decision ultimately depends on a developer's comfort with either technology, the target audience's browser usage, and the specific needs of a project, balancing immediate efficiency with long-term scalability.