Building applications with drag-and-drop functionality can be complex with traditional JavaScript, but React DnD offers a set of utilities that streamline the process, making it ideal for applications like Trello, ProofHub, and ClickUp that utilize project organization via boards. React DnD is built on React's declarative rendering philosophy, working seamlessly with Redux and other unidirectional data flow architectures, and supports HTML5 drag-and-drop by default, though custom backends can be utilized. This tutorial walks through creating a Trello clone using React DnD, detailing the construction of various components like Column, CardItem, Window, DropContainer, and Home, each playing a role in managing draggable cards and their states across different project columns. The tutorial emphasizes the efficiency and flexibility of React DnD, highlighting its automatic handling of browser-specific issues in HTML5 drag-and-drop and its integration with existing React and JavaScript features to enhance development speed and application performance.