APIs are crucial for modern digital communication, necessitating robust API gateways to manage traffic, ensure security, and provide operational metrics. As API gateways become targets for increasingly sophisticated cyber threats, organizations must implement comprehensive security architectures, including authentication, authorization, and threat prevention measures, to protect against attacks like DDoS and SQL injection. Traditional static security controls are insufficient for today's complex environments, where APIs can span multiple regions and organizations. Best practices for securing APIs include using HTTPS, rotating SSL certificates, implementing rate limiting, and employing modern security protocols such as OAuth 2.0 and mTLS. Additionally, monitoring tools like SIEM and SOAR can enhance visibility and automate threat response, while the zero-trust model and service meshes like Kuma provide granular security at the service level. Together, these strategies and technologies form a multi-layered defense for safeguarding API-centric architectures against evolving threats, ensuring the reliability and integrity of interconnected services.