Alert fatigue is a significant issue for modern on-call teams, caused by excessive and redundant notifications that desensitize engineers and lead to missed critical incidents. This guide emphasizes strategies such as centralizing incident data, implementing intelligent alert grouping, and using automation to reduce noise and improve response times. By prioritizing alerts based on contextual information and automating triage and response workflows, teams can focus on resolving important issues quickly and effectively. Bulk actions and continuous training further empower teams to manage alerts efficiently, while reviewing and optimizing alerting strategies and scheduling can minimize fatigue and improve morale. Leveraging AI and automation enhances alert management by providing context and suggesting actions, leading to significant improvements in detection and resolution times.