Managing GitHub notifications efficiently is essential for maintaining productivity, especially when dealing with a high volume of alerts from active projects or company repositories. Key strategies include reducing unnecessary notifications by unwatching irrelevant repositories, leaving non-essential teams, and locking or unsubscribing from outdated conversations. Prioritizing notifications can be achieved by understanding the reasons behind them, utilizing email headers, and setting up filters to direct emails to specific folders, allowing users to focus on high-priority alerts. Organizing notifications in an email client can further streamline workflow by enabling options like "Include your own updates" and filtering them accordingly. Users are encouraged to frequently review their recent work through their created pull requests and issues pages to maintain continuity in their projects. These practices help in managing notifications effectively, ensuring that users can focus on what truly matters and maintain efficiency in their collaborative endeavors on GitHub.