AI voice agents are increasingly utilized in customer service, entertainment, and enterprise applications, necessitating a comprehensive safety framework to ensure responsible use. This framework comprises pre-production safeguards such as red teaming and simulation, in-conversation enforcement mechanisms like guardrails and disclosure, and post-deployment ongoing monitoring. Key components include informing users they are interacting with an AI, establishing behavioral boundaries, and implementing a system prompt to enforce these limits. The framework also emphasizes privacy protection, escalation procedures, and live message moderation to prevent the dissemination of prohibited content. By conducting red teaming simulations and defining evaluation criteria, organizations can stress-test AI voice agents to uncover weaknesses and ensure they adhere to safety standards before deployment. Continuous monitoring and assessment allow for the identification of patterns and necessary adjustments to maintain compliance and build user trust.