PyScript is a front-end web framework that allows developers to run Python code directly in web browsers using HTML, offering an innovative approach to building browser-based applications with Python. Developed by Anaconda and built on Pyodide, PyScript simplifies the integration of Python scripts in HTML, supporting features such as external package usage, Python-Javascript interoperability, and in-browser data visualization. Although still in its alpha stage and not yet ready for production, PyScript provides an intuitive interface for developers, especially those in data science, to leverage Python's capabilities on the client side. It contrasts with Pyodide, which offers more extensive functionality, including the ability to handle C-based packages, making it suitable for performance-heavy applications. By utilizing tools like Earthly for reproducible builds, developers can enhance their PyScript application development process, ensuring consistent results.