Multi-region application architecture is a strategy for achieving high availability and risk mitigation by distributing applications and their databases across multiple cloud provider regions and availability zones. This approach ensures that critical applications remain operational during regional outages, natural disasters, or infrastructure failures by automatically routing traffic to functioning regions. It distinguishes between regions, which are geographic locations with independent data centers, and availability zones, which are isolated areas within a region, highlighting the latter's potential vulnerability if co-located. Multi-region architecture also enhances data security, compliance, and business continuity by replicating data across regions, thus reducing the impact of data breaches or losses. Although traditionally seen as expensive and complex, the advent of Distributed SQL and serverless computing has reduced these barriers, offering scalable, cost-effective solutions for deploying multi-region applications. Despite its benefits, adoption remains low due to the challenges of managing multi-region databases and associated costs, but technologies like CockroachDB Serverless are emerging as potential solutions to these issues.