CockroachDB 22.1 introduces a REST API that allows users to automate database operations by managing clusters programmatically instead of through the web interface. To use the CockroachDB Cloud API, users must obtain a secret key via a CockroachDB cloud account, which uses bearer token authentication. With the API, users can list clusters, create new clusters with specified parameters, retrieve detailed cluster and node information, adjust serverless spend limits, and delete clusters. Additionally, the API allows for the creation and deletion of SQL users. These operations are executed through specific API requests, each requiring the user's unique secret key and relevant cluster identifiers. The API is capable of performing a wide range of operations, as detailed in its comprehensive documentation.