dYdX, a decentralized trading platform for crypto derivatives, has seen significant advancements since its inception in 2017, including migrating to Starkware for lower transaction fees and developing the dYdX Chain as a standalone Cosmos appchain to enhance decentralization. The integration of Circle's USDC and Cross-Chain Transfer Protocol (CCTP) has been pivotal in facilitating seamless and secure transactions on both dYdX v3 and the newer dYdX Chain, enabling it to process over $20 billion in trading volume. Circle and Noble collaborated to introduce a Cosmos-native USDC, enhancing liquidity and enabling efficient transfers across blockchains. This integration has allowed for a more capital-efficient trading experience by eliminating reliance on third-party bridged USDC forms, leveraging native burning and minting of USDC to maintain security and efficiency. The dYdX Chain, supported by validators and the dYdX Ops SubDAO, has processed over $10 billion in trading volume, showcasing the impact of these innovations on the platform's growth and performance.